Wang ZM, Ying Z, Bosy-Westphal A, Zhang J, Later W, Heymsfield SB, et al. Specific metabolic rates of major organs and tissues across adulthood evaluation by mechanistic model of resting energy expenditure. Am J Clin Nutr. 2010;92:1396–77.
Article
CAS
Google Scholar
Bodine SC, Stitt TN, Gonzalez M, Kline WO, Stover GL, Bauerlein R, et al. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol. 2001;3:1014–9.
Article
CAS
PubMed
Google Scholar
Goodman CA, Frey JW, Mabrey DM, Jacobs BL, Lincoln HC, You JS, et al. The role of skeletal muscle mTOR in the regulation of mechanical load-induced growth. J Physiol. 2011;589:5485–501.
Article
CAS
PubMed
PubMed Central
Google Scholar
Baar K, Esser K. Phosphorylation of p70(S6k) correlates with increased skeletal muscle mass following resistance exercise. Am J Phys. 1999;276:C120–7.
Article
CAS
Google Scholar
Mitchell CJ, Churchward-Venne TA, Bellamy L, Parise G, Baker SK, Phillips SM. Muscular and systemic correlates of resistance training-induced muscle hypertrophy. PLoS One. 2013;8:e78636.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ogasawara R, Fujita S, Hornberger TA, Kitaoka Y, Makanae Y, Nakazato K, et al. The role of mTOR signalling in the regulation of skeletal muscle mass in a rodent model of resistance exercise. Sci Rep. 2016;6:31142.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bond P. Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance. J Int Soc Sports Nutr. 2016;13:s12970–016-0118-y.
Article
CAS
Google Scholar
Nakashima K, Yakabe Y. AMPK activation stimulates myofibrillar protein degradation and expression of atrophy-related ubiquitin ligases by increasing FOXO transcription factors in C2C12 myotubes. Biosci Biotechnol Biochem. 2007;71:1650–6.
Article
CAS
PubMed
Google Scholar
Russell RC, Yuan HX, Guan KL. Autophagy regulation by nutrient signaling. Cell Res. 2014;24:42–57.
Article
CAS
PubMed
Google Scholar
Bodine SC, Baehr LM. Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1. Am J Physiol Endocrinol Metab. 2014;307:E469–84.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zachari M, Ganley IG. The mammalian ULK1 complex and autophagy initiation. Essays Biochem. 2017;61:585–96.
Article
PubMed
PubMed Central
Google Scholar
Burd NA, Holwerda AM, Selby KC, West DW, Staples AW, Cain NE, et al. Resistance exercise volume affects myofibrillar protein synthesis and anabolic signalling molecule phosphorylation in young men. J Physiol. 2010;588:3119–30.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fujita S, Dreyer HC, Drummond MJ, Glynn EL, Cadenas JG, Yoshizawa F, et al. Nutrient signalling in the regulation of human muscle protein synthesis. J Physiol. 2007;582:813–23.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kunkel SD, Suneja M, Ebert SM, Bongers KS, Fox DK, Malmberg SE, et al. mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass. Cell Metab. 2011;13:627–38.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ogasawara R, Sato K, Higashida K, Nakazato K, Fujita S. Ursolic acid stimulates mTORC1 signaling after resistance exercise in rat skeletal muscle. Am J Physiol Endocrinol Metab. 2013;305:E760–5.
Article
CAS
PubMed
Google Scholar
Ogasawara R, Suginohara T. Rapamycin-insensitive mechanistic target of rapamycin regulates basal and resistance exercise-induced muscle protein synthesis. FASEB J. 2018;32:5824–34.
Article
CAS
Google Scholar
Ikeda Y, Murakami A, Ohigashi H. Ursolic acid: an anti- and pro-inflammatory triterpenoid. Mol Nutr Food Res. 2008;52:26–42.
Article
CAS
PubMed
Google Scholar
Kulling SE, Rawel HM. Chokeberry (aronia melanocarpa) - a review on the characteristic components and potential health effects. Planta Med. 2008;74:1625–34.
Article
CAS
PubMed
Google Scholar
Zapolska-Downar D, Bryk D, Malecki M, Hajdukiewicz K, Sitkiewicz D. Aronia melanocarpa fruit extract exhibits anti-inflammatory activity in human aortic endothelial cells. Eur J Nutr. 2012;51:563–72.
Article
CAS
PubMed
Google Scholar
Blomstrand E, Eliasson J, Karlsson HK, Köhnke R. Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise. J Nutr. 2006;136:269S–73S.
Article
CAS
PubMed
Google Scholar
Dreyer HC, Drummond MJ, Pennings B, Fujita S, Glynn EL, Chinkes DL, et al. Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle. Am J Physiol Endocrinol Metab. 2008;294:E392–400.
Article
CAS
PubMed
Google Scholar
Karlsson HK, Nilsson PA, Nilsson J, Chibalin AV, Zierath JR, Blomstrand E. Branched-chain amino acids increase p70S6k phosphorylation in human skeletal muscle after resistance exercise. Am J Physiol Endocrinol Metab. 2004;287:E1–7.
Article
CAS
PubMed
Google Scholar
Borgenvik M, Apro W, Blomstrand E. Intake of branched-chain amino acids influences the levels of MAFbx mRNA and MuRF-1 total protein in resting and exercising human muscle. Am J Physiol Endocrinol Metab. 2012;302:E510–21.
Article
CAS
PubMed
Google Scholar
Willoughby DS, Stout JR, Wilborn CD. Effects of resistance training and protein plus amino acid supplementation on muscle anabolism, mass, and strength. Amino Acids. 2007;32:467–77.
Article
CAS
PubMed
Google Scholar
You JS, McNally RM, Jacobs BL, Privett RE, Gundermann DM, Lin KH, et al. The role of raptor in the mechanical load-induced regulation of mTOR signaling, protein synthesis, and skeletal muscle hypertrophy. FASEB J. 2019;33:4021–34.
Article
CAS
PubMed
Google Scholar
Jung CH, Ro SH, Cao J, Otto NM, Kim DH. mTOR regulation of autophagy. FEBS Lett. 2010;584:1287–95.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhao J, Zhai B, Gygi SP, Goldberg AL. mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy. Proc Natl Acad Sci U S A. 2015;112:15790–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nakazato K, Ochi E, Waga T. Dietary apple polyphenols have preventive effects against lengthening contraction-induced muscle injuries. Mol Nutr Food Res. 2010;54:364–72.
Article
CAS
PubMed
Google Scholar
Makanae Y, Ogasawara R, Sato K, Takamura Y, Matsutani K, Kido K, et al. Acute bout of resistance exercise increases vitamin D receptor protein expression in rat skeletal muscle. Exp Physiol. 2015;100:1168–76.
Article
CAS
PubMed
Google Scholar
Goodman CA, Mabrey DM, Frey JW, Miu MH, Schmidt EK, Pierre P, et al. Novel insights into the regulation of skeletal muscle synthesis as revealed by a new nonradioactive in vivo technique. FASEB J. 2011;25:1028–39.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ato S, Makanae Y, Kido K, Fujita S. Contraction mode itself does not determine the level of mTORC1 activity in rat skeletal muscle. Physiol Rep. 2016;4:e12976.
Article
PubMed
PubMed Central
CAS
Google Scholar
Kido K, Sato K, Makanae Y, Ato S, Hayashi T, Fujita S. Herbal supplement Kamishimotsuto augments resistance exercise-induced mTORC1 signaling in rat skeletal muscle. Nutrition. 2016;32:108–13.
Article
CAS
PubMed
Google Scholar
Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 2011;13:132–41.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mizushima N. The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol. 2010;22:132–9.
Article
CAS
PubMed
Google Scholar
Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000;19:5720–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lee J, Giordano S, Zhang J. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J. 2012;441:523–40.
Article
CAS
PubMed
Google Scholar
Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol. 2002;4:648–57.
Article
CAS
PubMed
Google Scholar
Miyazaki M, McCarthy JJ, Fedele MJ, Esser KA. Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling. J Physiol. 2011;589:1831–46.
Article
CAS
PubMed
PubMed Central
Google Scholar
You JS, Frey JW, Hornberger TA. Mechanical stimulation induces mTOR signaling via an ERK-independent mechanism: implications for a direct activation of mTOR by phosphatidic acid. PLoS One. 2012;7:e47258.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kim JH, Auger C, Kurita I, Anselm E, Rivoarilala LO, Lee HJ, et al. Aronia melanocarpa juice, a rich source of polyphenols, induces endothelium-dependent relaxations in porcine coronary arteries via the redox-sensitive activation of endothelial nitric oxide synthase. Nitric Oxide. 2013;35:54–64.
Article
CAS
PubMed
Google Scholar
Goodman CA, Mayhew DL, Hornberger TA. Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass. Cell Signal. 2011;23:1896–906.
Article
CAS
PubMed
PubMed Central
Google Scholar
Phillips SM. A brief review of critical processes in exercise-induced muscular hypertrophy. Sports Med. 2014;44:S71–7.
Article
PubMed
Google Scholar
Mitchell CJ, Churchward-Venne TA, Parise G, Bellamy L, Smith K, et al. Acute post-exercise myofibrillar protein synthesis is not correlated with resistance training-induced muscle hypertrophy in young men. PLoS One. 2014;9:e89431.
Article
PubMed
PubMed Central
CAS
Google Scholar
Bang HS, Seo DY, Chang YM, Oh KM, Park JJ, Arturo F, et al. Ursolic acid-induced elevation of serum irisin augments muscle strength during resistance training in men. Korean J Physiol Phamacol. 2014;18:441–6.
Article
CAS
Google Scholar
Chen J, Wong HS, Leong PK, Leung HY, Chan WM, Ko KM. Ursolic acid induces mitochondrial biogenesis through the activation of AMPK and PGC-1 in C2C12 myotubes: a possible mechanism underlying its beneficial effect on exercise endurance. Food Funct. 2017;8:2425–36.
Article
CAS
PubMed
Google Scholar
Chu X, He X, Shi Z, Li C, Guo F, Li S, et al. Ursolic acid increases energy expenditure through enhancing free fatty acid uptake and beta-oxidation via an UCP3/AMPK-dependent pathway in skeletal muscle. Mol Nutr Food Res. 2015;59:1491–503.
Article
CAS
PubMed
Google Scholar
Lee YK, Lee WS, Kim GS, Park OJ. Anthocyanins are novel AMPKalpha1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation. Oncol Rep. 2010;24:1471–7.
PubMed
Google Scholar
Ong KW, Hsu A, Tan BK. Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes. PLoS One. 2012;7:e32718.
Article
CAS
PubMed
PubMed Central
Google Scholar
Talagavadi V, Rapisarda P, Galvano F, Pelicci P, Giorgio M. Cyanidin-3-O-β-glucoside and protocatechuic acid activate AMPK/mTOR/S6K pathway and improve glucose homeostasis in mice. J Funct Foods. 2016;21:338–48.
Article
CAS
Google Scholar
Ato S, Makanae Y, Kido K, Sase K, Yoshii N, Fujita S. The effect of different muscle contraction regimens on the expression of muscle proteolytic signaling proteins and genes. Physiol Rep. 2017;5:e13364.
Article
PubMed
PubMed Central
CAS
Google Scholar
Atherton PJ, Etheridge T, Watt PJ, Wilkinson D, Selby A, Randkin D, et al. Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling. Am J Clin Nutr. 2010;92:1080–8.
Article
CAS
PubMed
Google Scholar