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The effects of pre versus post workout supplementation of creatine monohydrate on body composition and strength


Chronic supplementation with creatine monohydrate has been shown to promote increases in intramuscular total creatine, phosphocreatine, skeletal muscle mass, lean body mass and muscle fiber size. Furthermore, there is robust evidence that muscular strength and power will also increase after supplementing with creatine. However, it is not known if the timing of creatine supplementation will affect the adaptive response to exercise. Thus, the purpose of this investigation was to determine the difference between pre versus post exercise supplementation of creatine on measures of body composition and strength.


Nineteen healthy recreational male bodybuilders (age: 22.87+ 2.90; height: 172.69+ 13.39cm; weight: 80.18+ 10.43kg) participated in this study. Subjects were randomly assigned to one of the following groups: PRE-SUPP or POST-SUPP workout supplementation of creatine (5 grams). The PRE-SUPP group consumed 5 grams of creatine immediately before exercise. On the other hand, the POST-SUPP group consumed 5 grams immediately after exercise. Subjects trained on average five days per week for four weeks. Subjects consumed the supplement on the two non-training days at their convenience. Subjects performed a periodized, split-routine, bodybuilding workout five days per week (Chest-shoulders-triceps; Back-biceps, Legs, etc). Body composition (Bod Pod®) and 1-RM bench press were determined. Diet logs were collected and analyzed (one random day per week; four total days analyzed).


2x2 ANOVA results - There was a significant time effect for FFW (F=19.9; p=0.001) and BP (F=18.9; p<0.001), however FM and BW did not reach significance. While there were trends, no significant interactions were found.

Table 1 Body composition and strength
Table 2 Magnitude-based inference results


Creatine supplementation plus resistance exercise increases fat-free mass and strength. Based on the magnitude inferences it appears that consuming creatine immediately post-workout is superior to pre-workout vis a vis body composition and strength.


The creatine monohydrate (Creatine Plasma™) was provided by VPX® Sports, Davie FL. Many thanks to Jeff Stout PhD for running the stats on this project. Disclosures: Jose Antonio PhD is a sports science consultant to VPX® Sports.

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Correspondence to Jose Antonio.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated.

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Ciccone, V., Cabrera, K. & Antonio, J. The effects of pre versus post workout supplementation of creatine monohydrate on body composition and strength. J Int Soc Sports Nutr 10 (Suppl 1), P1 (2013).

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