Persky A, Brazeau G: Clinical pharmacology of the dietary supplement creatine monohydrate. Pharmacol Rev. 2001, 53: 161-176.
CAS
PubMed
Google Scholar
Burke DG, Candow DG, Chilibeck PD, MacNeil LG, Roy BD, Tarnopolsky MA, Ziegenfuss T: Effect of creatine supplementation and resistance-exercise training on muscle insulin-like growth factor in young adults. Int J Sport Nutr Exerc Metab. 2008, 18: 389-398.
CAS
PubMed
Google Scholar
Gualano B, Artioli GG, Poortmans JR, Lancha Junior AH: Exploring the therapeutic role of creatine supplementation. Amino Acids. 2010, 38: 31-44. 10.1007/s00726-009-0263-6.
Article
CAS
PubMed
Google Scholar
Tarnopolsky MA: Creatine as a therapeutic strategy for myopathies. Amino Acids. 2011, 40: 1397-1407. 10.1007/s00726-011-0876-4.
Article
CAS
PubMed
Google Scholar
Buford T, Kreider R, Stout J, Greenwood M, Campbell B, Spano M, Ziegenfuss T, Lopez H, Landis J, Antonio J: International Society of Sports Nutrition position stand: creatine supplementation and exercise. J Int Soc Sports Nutr. 2007, 4: 6-10.1186/1550-2783-4-6.
Article
PubMed Central
PubMed
Google Scholar
American College of Sport Medicine: Round Table, the physiological and health effects of oral creatine supplementation. Med Sci Sports Exc. 2000, 32: 706-717.
Article
Google Scholar
Branch JD: Effects of creatine supplementation on body composition and performace: a meta análisis. Int J Sports Nutr Exerc Metabol. 2003, 13: I198-122-
Google Scholar
Rawson ES, Volek JS: Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance. J Strength Cond Res. 2003, 17: 822-831.
PubMed
Google Scholar
Volek JS, Kraemer WJ: Creatine suplemetation: its effects on human muscular performance and body composition. J Strength Cond Res. 1996, 10: 200-210.
Google Scholar
Bemben M, Lamont H: Creatine supplementation and exercise performance: recent findings. Sports Med. 2005, 35: 107-125. 10.2165/00007256-200535020-00002.
Article
PubMed
Google Scholar
Brosnan JT, da Silva RP, Brosnan ME: The metabolic burden of creatine synthesis. Amino Acids. 2011, 40: 1325-1331. 10.1007/s00726-011-0853-y.
Article
CAS
PubMed
Google Scholar
Snow RJ, Murphy RM: Creatine and the creatine transporter: a review. Mol Cell Biochem. 2001, 224: 169-181. 10.1023/A:1011908606819.
Article
CAS
PubMed
Google Scholar
Snow RJ, Murphy RM: Factors influencing creatine loading into human skeletal muscle. Exerc Sport Sci Rev. 2003, 31: 154-158. 10.1097/00003677-200307000-00010.
Article
PubMed
Google Scholar
Schoch RD, Willoughby D, Greenwood M: The regulation and expression of the creatine transporter: a brief review of creatine supplementation in humans and animals. J Int Soc Sports Nutr. 2006, 3: 60-66. 10.1186/1550-2783-3-1-60.
Article
PubMed Central
PubMed
Google Scholar
Hickner R, Dyck D, Sklar J, Hatley H, Byrd P: Effect of 28 days of creatine ingestion on muscle metabolism and performance of a simulated cycling road race. J Int Soc Sports Nutr. 2010, 7: 26-10.1186/1550-2783-7-26.
Article
PubMed Central
PubMed
Google Scholar
Hespel P, Derave W: Ergogenic effects of creatine in sports and rehabilitation. Subcell Biochem. 2007, 46: 245-259. 10.1021/bi061646s.
Article
PubMed
Google Scholar
Casey A, Greenhaff P: Does dietary creatine supplementation play a role in skeletal muscle metabolism and performance?. Am J Clin Nutr. 2000, 72: 607S-617S.
CAS
PubMed
Google Scholar
Volek J, Duncan N, Mazzetti S, Staron R, Putukian M, Gómez A, Pearson D, Fink W, Kraemer W: Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Med Sci Sports Exerc. 1999, 31: 1147-1156. 10.1097/00005768-199908000-00011.
Article
CAS
PubMed
Google Scholar
Dempsey R, Mazzone M, Meurer L: Does oral creatine supplementation improve strength? A meta-analysis. J Fam Pract. 2002, 51: 945-951.
PubMed
Google Scholar
Kreider RB: Effects of creatine supplementation on performance and training adaptations. Mol Cell Biochem. 2003, 244: 89-94. 10.1023/A:1022465203458.
Article
CAS
PubMed
Google Scholar
van Loon L, Oosterlaar A, Hartgens F, Hesselink M, Snow R, Wagenmakers A: Effects of creatine loading and prolonged creatine supplementation on body composition, fuel selection, sprint and endurance performance in humans. Clin Sci (Lond). 2003, 104: 153-162. 10.1042/CS20020159.
Article
CAS
Google Scholar
Volek J, Rawson E: Scientific basis and practical aspects of creatine supplementation for athletes. Nutrition. 2004, 20: 609-614. 10.1016/j.nut.2004.04.014.
Article
CAS
PubMed
Google Scholar
Jakobi J, Rice C, Curtin S, Marsh G: Contractile properties, fatigue and recovery are not influenced by short-term creatine supplementation in human muscle. Exp Physiol. 2000, 85: 451-460. 10.1017/S0958067000020212.
Article
CAS
PubMed
Google Scholar
Bemben MG, Witten MS, Carter JM, Eliot KA, Knehans AW, Bemben DA: The effects of supplementation with creatine and protein on muscle strength following a traditional resistance training program in middle-aged and older men. J Nutr Health Aging. 2010, 14: 155-159. 10.1007/s12603-009-0124-8.
Article
CAS
PubMed
Google Scholar
Safdar A, Yardley N, Snow R, Melov S, Tarnopolsky M: Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation. Physiol Genomics. 2008, 32: 219-228.
Article
CAS
PubMed
Google Scholar
Saremi A, Gharakhanloo R, Sharghi S, Gharaati M, Larijani B, Omidfar K: Effects of oral creatine and resistance training on serum myostatin and GASP-1. Mol Cell Endocrinol. 2010, 317: 25-30. 10.1016/j.mce.2009.12.019.
Article
CAS
PubMed
Google Scholar
Bazzucchi I, Felici F, Sacchetti M: Effect of short-term creatine supplementation on neuromuscular function. Med Sci Sports Exerc. 2009, 41: 1934-41. 10.1249/MSS.0b013e3181a2c05c.
Article
CAS
PubMed
Google Scholar
Branch J: Effect of creatine supplementation on body composition and performance: a meta-analysis. Int J Sport Nutr Exerc Metab. 2003, 13: 198-226.
CAS
PubMed
Google Scholar
Cribb PJ, Williams AD, Hayes A: A creatine-protein-carbohydrate supplement enhances responses to resistance training. Med Sci Sports Exerc. 2007, 39: 1960-1968. 10.1249/mss.0b013e31814fb52a.
Article
CAS
PubMed
Google Scholar
Parise G, Mihic S, MacLennan D, Yarasheski KE, Tarnopolsky MA: Effects of acute creatine monohydrate supplementation on leucine kinetics and mixed-muscle protein synthesis. J Appl Physiol. 2001, 91: 1041-1047.
CAS
PubMed
Google Scholar
Louis M, Poortmans JR, Francaux M, Hultman E, Berre J, Boisseau N, Young VR, Smith K, Meier-Augenstein W, Babraj JA, et al: Creatine supplementation has no effect on human muscle protein turnover at rest in the postabsorptive or fed states. Am J Physiol Endocrinol Metab. 2003, 284: E764-E770.
Article
CAS
PubMed
Google Scholar
Deldicque L, Atherton P, Patel R, Theisen D, Nielens H, Rennie M, Francaux M: Effects of resistance exercise with and without creatine supplementation on gene expression and cell signaling in human skeletal muscle. J Appl Physiol. 2008, 104: 371-378.
Article
CAS
PubMed
Google Scholar
Harp JB, Goldstein S, Phillips LS: Nutrition and somatomedin. XXIII. Molecular regulation of IGF-I by amino acid availability in cultured hepatocytes. Diabetes. 1991, 40: 95-101. 10.2337/diabetes.40.1.95.
Article
CAS
PubMed
Google Scholar
Chwalbiñska-Moneta J: Effect of creatine supplementation on aerobic performance and anaerobic capacity in elite rowers in the course of endurance training. Int J Sport Nutr Exerc Metab. 2003, 13: 173-183.
PubMed
Google Scholar
Graef J, Smith A, Kendall K, Fukuda D, Moon J, Beck T, Cramer J, Stout J: The effects of four weeks of creatine supplementation and high-intensity interval training on cardiorespiratory fitness: a randomized controlled trial. J Int Soc Sports Nutr. 2009, 6: 18-10.1186/1550-2783-6-18.
Article
PubMed Central
PubMed
Google Scholar
Thompson C, Kemp G, Sanderson A, Dixon R, Styles P, Taylor D, Radda G: Effect of creatine on aerobic and anaerobic metabolism in skeletal muscle in swimmers. Br J Sports Med. 1996, 30: 222-225. 10.1136/bjsm.30.3.222.
Article
PubMed Central
CAS
PubMed
Google Scholar
Nelson A, Arnall D, Kokkonen J, Day R, Evans J: Muscle glycogen supercompensation is enhanced by prior creatine supplementation. Med Sci Sports Exerc. 2001, 33: 1096-1100.
Article
CAS
PubMed
Google Scholar
Sewell D, Robinson T, Greenhaff P: Creatine supplementation does not affect human skeletal muscle glycogen content in the absence of prior exercise. J Appl Physiol. 2008, 104: 508-512.
Article
CAS
PubMed
Google Scholar
Op 't Eijnde B, Urso B, Richter EA, Greenhaff PL, Hespel P: Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization. Diabetes. 2001, 50: 18-23. 10.2337/diabetes.50.1.18.
Article
PubMed
Google Scholar
Bassit RA, Pinheiro CH, Vitzel KF, Sproesser AJ, Silveira LR, Curi R: Effect of short-term creatine supplementation on markers of skeletal muscle damage after strenuous contractile activity. Eur J Appl Physiol. 2010, 108: 945-955. 10.1007/s00421-009-1305-1.
Article
CAS
PubMed
Google Scholar
Cooke MB, Rybalka E, Williams AD, Cribb PJ, Hayes A: Creatine supplementation enhances muscle force recovery after eccentrically-induced muscle damage in healthy individuals. J Int Soc Sports Nutr. 2009, 6: 13-10.1186/1550-2783-6-13.
Article
PubMed Central
PubMed
Google Scholar
Lawler JM, Barnes WS, Wu G, Song W, Demaree S: Direct antioxidant properties of creatine. Biochem Biophys Res Commun. 2002, 290: 47-52. 10.1006/bbrc.2001.6164.
Article
CAS
PubMed
Google Scholar
Sestili P, Martinelli C, Bravi G, Piccoli G, Curci R, Battistelli M, Falcieri E, Agostini D, Gioacchini AM, Stocchi V: Creatine supplementation affords cytoprotection in oxidatively injured cultured mammalian cells via direct antioxidant activity. Free Radic Biol Med. 2006, 40: 837-849. 10.1016/j.freeradbiomed.2005.10.035.
Article
CAS
PubMed
Google Scholar
Rahimi R: Creatine supplementation decreases oxidative DNA damage and lipid peroxidation induced by a single bout of resistance exercise. J Strength Cond Res. 2011, 25: 3448-3455. 10.1519/JSC.0b013e3182162f2b.
Article
PubMed
Google Scholar
Sculthorpe N, Grace F, Jones P, Fletcher I: The effect of short-term creatine loading on active range of movement. Appl Physiol Nutr Metab. 2010, 35: 507-511. 10.1139/H10-036.
Article
CAS
PubMed
Google Scholar
Hile A, Anderson J, Fiala K, Stevenson J, Casa D, Maresh C: Creatine supplementation and anterior compartment pressure during exercise in the heat in dehydrated men. J Athl Train. 2006, 41: 30-35.
PubMed Central
PubMed
Google Scholar
Hammett S, Wall M, Edwards T, Smith A: Dietary supplementation of creatine monohydrate reduces the human fMRI BOLD signal. Neurosci Lett. 2010, 479: 201-205. 10.1016/j.neulet.2010.05.054.
Article
CAS
PubMed
Google Scholar
D'Anci KE, Allen PJ, Kanarek RB: A potential role for creatine in drug abuse?. Mol Neurobiol. 2011, 44: 136-41. 10.1007/s12035-011-8176-2.
Article
PubMed
Google Scholar
Rawson ES, Venezia AC: Use of creatine in the elderly and evidence for effects on cognitive function in young and old. Amino Acids. 2011, 40: 1349-1362. 10.1007/s00726-011-0855-9.
Article
CAS
PubMed
Google Scholar
Beal MF: Neuroprotective effects of creatine. Amino Acids. 2011, 40: 1305-1313. 10.1007/s00726-011-0851-0.
Article
CAS
PubMed
Google Scholar
Braissant O, Henry H, Béard E, Uldry J: Creatine deficiency syndromes and the importance of creatine synthesis in the brain. Amino Acids. 2011, 40: 1315-1324. 10.1007/s00726-011-0852-z.
Article
CAS
PubMed
Google Scholar
Metzl JD, Small E, Levine SR, Gershel JC: Creatine use among young athletes. Pediatrics. 2001, 108: 421-425. 10.1542/peds.108.2.421.
Article
CAS
PubMed
Google Scholar
Evans MW, Ndetan H, Perko M, Williams R, Walker C: Dietary supplement use by children and adolescents in the United States to Enhance sport performance: results of the national health interview survey. J Prim Prev. 2012, 33: 3-12. 10.1007/s10935-012-0261-4.
Article
PubMed
Google Scholar
Unnithan VB, Veehof SH, Vella CA, Kern M: Is there a physiologic basis for creatine use in children and adolescents?. J Strength Cond Res. 2001, 15: 524-528.
CAS
PubMed
Google Scholar
Willoughby DS, Rosene J: Effects of oral creatine and resistance training on myosin heavy chain expression. Med Sci Sports Exerc. 2001, 33: 1674-1681. 10.1097/00005768-200110000-00010.
Article
CAS
PubMed
Google Scholar
Sale C, Harris RC, Florance J, Kumps A, Sanvura R, Poortmans JR: Urinary creatine and methylamine excretion following 4 x 5 g x day(-1) or 20 x 1 g x day(-1) of creatine monohydrate for 5 days. J Sports Sci. 2009, 27: 759-766. 10.1080/02640410902838237.
Article
PubMed
Google Scholar
Syrotuik DG, Bell GJ: Acute creatine monohydrate supplementation: a descriptive physiological profile of responders vs. nonresponders. J Strength Cond Res. 2004, 18: 610-617.
PubMed
Google Scholar
Greenhaff PL, Bodin K, Soderlund K, Hultman E: Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis. Am J Physiol. 1994, 266: E725-E730.
CAS
PubMed
Google Scholar
Ganguly S, Jayappa S, Dash AK: Evaluation of the stability of creatine in solution prepared from effervescent creatine formulations. AAPS PharmSciTech. 2003, 4: E25-
Article
PubMed
Google Scholar
Jäger R, Harris RC, Purpura M, Francaux M: Comparison of new forms of creatine in raising plasma creatine levels. J Int Soc Sports Nutr. 2007, 4: 17-10.1186/1550-2783-4-17.
Article
PubMed Central
PubMed
Google Scholar
Jäger R, Metzger J, Lautmann K, Shushakov V, Purpura M, Geiss K, Maassen N: The effects of creatine pyruvate and creatine citrate on performance during high intensity exercise. J Int Soc Sports Nutr. 2008, 5: 4-10.1186/1550-2783-5-4.
Article
PubMed Central
PubMed
Google Scholar
Jäger R, Purpura M, Shao A, Inoue T, Kreider RB: Analysis of the efficacy, safety, and regulatory status of novel forms of creatine. Amino Acids. 2011, 40: 1369-83. 10.1007/s00726-011-0874-6.
Article
PubMed Central
PubMed
Google Scholar
Gufford BT, Sriraghavan K, Miller N, Miller D, Gu X, Vennerstrom J, Robinson D: Physicochemical characterization of creatine N-methylguanidinium salts. Journal of Dietary Supplements. 2010, 7: 240-252. 10.3109/19390211.2010.491507.
Article
PubMed
Google Scholar
Persky AM, Brazeau GA, Hochhaus G: Pharmacokinetics of the dietary supplement creatine. Clin Pharmacokinet. 2003, 42: 557-574. 10.2165/00003088-200342060-00005.
Article
CAS
PubMed
Google Scholar
Spillane M, Schoch R, Cooke M, Harvey T, Greenwood M, Kreider R, Willoughby DS: The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels. J Int Soc Sports Nutr. 2009, 6: 6-10.1186/1550-2783-6-6.
Article
PubMed Central
PubMed
Google Scholar
Knop K, Hoogenboom R, Fischer D, Schubert US: Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. Angew Chem Int Ed Engl. 2010, 49: 6288-6308. 10.1002/anie.200902672.
Article
CAS
PubMed
Google Scholar
Camic CL, Hendrix CR, Housh TJ, Zuniga JM, Mielke M, Johnson GO, Schmidt RJ, Housh DJ: The effects of polyethylene glycosylated creatine supplementation on muscular strength and power. J Strength Cond Res. 2010, 24: 3343-3351. 10.1519/JSC.0b013e3181fc5c5c.
Article
PubMed
Google Scholar
Herda TJ, Beck TW, Ryan ED, Smith AE, Walter AA, Hartman MJ, Stout JR, Cramer JT: Effects of creatine monohydrate and polyethylene glycosylated creatine supplementation on muscular strength, endurance, and power output. J Strength Cond Res. 2009, 23: 818-826. 10.1519/JSC.0b013e3181a2ed11.
Article
PubMed
Google Scholar
Steenge GR, Lambourne J, Casey A, Macdonald IA, Greenhaff PL: Stimulatory effect of insulin on creatine accumulation in human skeletal muscle. Am J Physiol. 1998, 275: E974-E979.
CAS
PubMed
Google Scholar
Steenge G, Simpson E, Greenhaff P: Protein- and carbohydrate-induced augmentation of whole body creatine retention in humans. J Appl Physiol. 2000, 89: 1165-1171.
CAS
PubMed
Google Scholar
Olsen S, Aagaard P, Kadi F, Tufekovic G, Verney J, Olesen JL, Suetta C, Kjaer M: Creatine supplementation augments the increase in satellite cell and myonuclei number in human skeletal muscle induced by strength training. J Physiol. 2006, 573: 525-534. 10.1113/jphysiol.2006.107359.
Article
PubMed Central
CAS
PubMed
Google Scholar
Walsh AL, Gonzalez AM, Ratamess NA, Kang J, Hoffman JR: Improved time to exhaustion following ingestion of the energy drink Amino Impact. J Int Soc Sports Nutr. 2010, 7: 14-10.1186/1550-2783-7-14.
Article
PubMed Central
PubMed
Google Scholar
Yoshizumi W, Tsourounis C: Effects of creatine supplementation on renal function. J Herb Pharmacother. 2004, 4: 1-7.
Article
CAS
PubMed
Google Scholar
Thorsteinsdottir B, Grande J, Garovic V: Acute renal failure in a young weight lifter taking multiple food supplements, including creatine monohydrate. J Ren Nutr. 2006, 16: 341-345. 10.1053/j.jrn.2006.04.025.
Article
PubMed
Google Scholar
Pline K, Smith C: The effect of creatine intake on renal function. Ann Pharmacother. 2005, 39: 1093-1096. 10.1345/aph.1E628.
Article
CAS
PubMed
Google Scholar
Poortmans J, Francaux M: Adverse effects of creatine supplementation: fact or fiction?. Sports Med. 2000, 30: 155-170. 10.2165/00007256-200030030-00002.
Article
CAS
PubMed
Google Scholar
Bizzarini E, De Angelis L: Is the use of oral creatine supplementation safe?. J Sports Med Phys Fitness. 2004, 44: 411-416.
CAS
PubMed
Google Scholar
Kim HJ, Kim CK, Carpentier A, Poortmans JR: Studies on the safety of creatine supplementation. Amino Acids. 2011, 40: 1409-1418. 10.1007/s00726-011-0878-2.
Article
CAS
PubMed
Google Scholar
Tarnopolsky M, Zimmer A, Paikin J, Safdar A, Aboud A, Pearce E, Roy B, Doherty T: Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults. PLoS One. 2007, 2: e991-10.1371/journal.pone.0000991.
Article
PubMed Central
PubMed
Google Scholar
Cornelissen VA, Defoor JG, Stevens A, Schepers D, Hespel P, Decramer M, Mortelmans L, Dobbels F, Vanhaecke J, Fagard RH, Vanhees L: Effect of creatine supplementation as a potential adjuvant therapy to exercise training in cardiac patients: a randomized controlled trial. Clin Rehabil. 2010, 24: 988-999. 10.1177/0269215510367995.
Article
CAS
PubMed
Google Scholar
Schilling B, Stone M, Utter A, Kearney J, Johnson M, Coglianese R, Smith L, O'Bryant H, Fry A, Starks M, et al: Creatine supplementation and health variables: a retrospective study. Med Sci Sports Exerc. 2001, 33: 183-188.
Article
CAS
PubMed
Google Scholar
Dalbo V, Roberts M, Stout J, Kerksick C: Putting to rest the myth of creatine supplementation leading to muscle cramps and dehydration. Br J Sports Med. 2008, 42: 567-573. 10.1136/bjsm.2007.042473.
Article
CAS
PubMed
Google Scholar
Watson G, Casa D, Fiala K, Hile A, Roti M, Healey J, Armstrong L, Maresh C: Creatine use and exercise heat tolerance in dehydrated men. J Athl Train. 2006, 41: 18-29.
PubMed Central
PubMed
Google Scholar
Lopez R, Casa D, McDermott B, Ganio M, Armstrong L, Maresh C: Does creatine supplementation hinder exercise heat tolerance or hydration status? A systematic review with meta-analyses. J Athl Train. 2009, 44: 215-223. 10.4085/1062-6050-44.2.215.
Article
PubMed Central
PubMed
Google Scholar
Hadjicharalambous M, Kilduff L, Pitsiladis Y: Brain serotonin and dopamine modulators, perceptual responses and endurance performance during exercise in the heat following creatine supplementation. J Int Soc Sports Nutr. 2008, 5: 14-10.1186/1550-2783-5-14.
Article
PubMed Central
PubMed
Google Scholar