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Table 1 Comparison of Assay Methods Characterizing UC-II® Undenatured Type II Collagen

From: Letter to the editor UC-II® Undenatured type II collagen: update to analytical methods

UC-II® Study Design

Research Material (Lot No.)

Undenatured Type II Collagen (in 40-mg UC-II® material)

Per ELISA-Old Assay

Per ELISA-New Assay

Efficacy study - healthy adults*

1109006

10.8 mg (27.0%)

2.3 mg (5.8%)

Efficacy study – people with osteoarthritis **

1204004

10.8 mg (27.1%)

1.2 mg (3.0%)

Typical lot sold into commerce

1309029

10.6 mg (26.5%)

1.3 mg (3.3%)

  1. ELISA indicates enzyme-linked immunosorbent assay
  2. *Lugo et al. J Int Soc Sports Nutr. 2013;10:48
  3. **Lugo et al. Nutr J. 2016;15:14