Fig. 2

Mechanism for transcriptional activation by PPAR. Panel a shows the inactivated state, without gene transcriptional of any target genes. Panel b shows the activation of PPAR by PPAR ligands and RXR by 9-cis-RA (9-cis-retinoic acid), thereby stimulating target genes transcription by binding to specific DNA sequence (peroxisome proliferators – PPRE) leading to increased β-oxidation, mitochondrial biogenesis and insulin sensitivity