Fig. 2
![Fig. 2](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12970-015-0097-4/MediaObjects/12970_2015_97_Fig2_HTML.gif)
Mechanism for transcriptional activation by PPAR. Panel a shows the inactivated state, without gene transcriptional of any target genes. Panel b shows the activation of PPAR by PPAR ligands and RXR by 9-cis-RA (9-cis-retinoic acid), thereby stimulating target genes transcription by binding to specific DNA sequence (peroxisome proliferators – PPRE) leading to increased β-oxidation, mitochondrial biogenesis and insulin sensitivity