Background
While there are numerous natural products being marketed and sold that claim to help consumers lose body weight and body fat, very few undergo finished product-specific research demonstrating their safety and efficacy. Additionally, there is a growing interest in the role of adipokines in the development of Metabolic Syndrome and the regulation of body fat, blood pressure, insulin sensitivity, carbohydrate and lipid metabolism. The purpose of this study was to determine the safety and efficacy of a multi-ingredient supplement containing primarily raspberry ketone, caffeine, and Citrus aurantium (Prograde Metabolism™ [Metabo]) as an adjunct to an eight-week weight loss program.