Significantly faster half-marathon split (p = 0.002) and race finish (p = 0.001) times were reported for subjects in the TC group versus P. The overall MANOVA analyses revealed significant Wilks' Lambda time (p < 0.001) interactions, but no significant group × time pro-inflammatory (p = 0.90) and anti-inflammatory (p = 0.73) effects. All of the univariate measures for pro- and anti-inflammatory makers reported main time effects. The mean TC IL-1β result (p = 0.059) tended to be greater than P, but no between group change over time. A trend toward a significant group × time interaction was shown in IL-2 (p = 0.079) and IL-5 (p = 0.076) with a significantly greater TC IL-2 pre-run response and a greater TC IL-5 level over all five study time points compared to P. A significant group × time interaction was shown for IL-6 (p = 0.038) and IL-12p70 (p = 0.050) with a significantly greater TC IL-6 response at baseline, pre-run, and 60-min post-run compared to P. Post-hoc analysis indicated a significantly attenuated TC IL-12p70 response across all three post-run recovery time points compared to P. The overall delta MANOVA analyses revealed significant Wilks' Lambda time (p < 0.001) interactions, but no significant group × time pro-inflammatory (p = 0.77) and anti-inflammatory (p = 0.64) effects. Within the univariate analysis, changes in IL-2 (p = 0.10), IL-5 (p = 0.067), IL-12p70 (p = 0.036), and IL-13 (p = 0.096) from pre-run tended to be more significantly attenuated in TC over P coupled with a tendency for IL-2 (p = 0.098), IL-12p70 (p = 0.098), and IL-13 (p = 0.087) levels to be more greatly attenuated in TC compared to P. The 48-h recovery NT response from pre-run tended to be greater in TC compared to P. Post-hoc analysis revealed significantly attenuated changes in IL-2 and IL-5 from pre-run values at both 24-h and 48-h post-run in TC compared to P. These results were paired with significantly attenuated IL-13 levels from pre-run at 60-min and 48-h post-run, while the NT TC response was significantly greater and the IL-12p70 TC levels were significantly attenuated compared to P at 48-h post-run. While a main delta time effect was shown for IL-6 (p < 0.001), no significant delta changes between groups over time were observed (p = 0.16).