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Safety of Teacrine®, a Non-Habituating, Naturally-Occurring Purine Alkaloid Over Eight Weeks of Continuous Use

  • Sara Hayward1,
  • Jacy Mullins1,
  • Stacie Urbina1,
  • Emily Santos1,
  • Katelyn Villa1,
  • Nicole Viana1,
  • Shelbey Perkins1,
  • Jennifer Ander1,
  • Alyssa Olivencia1,
  • Shannon McGorty1,
  • Colin Wilborn1 and
  • Lem Taylor1Email author
Journal of the International Society of Sports Nutrition201512(Suppl 1):P59

Published: 12 November 2015


Theacrine (1,3,7,9-tetramethyluric acid) is a purine alkaloid found in certain coffee (Coffea) species, fruits (Cupuacu [Theobroma grandiflorum]), and tea (Camellia assamica, var. kucha) that has anti-inflammatory, analgesic, and neuro-locomotor properties. Recent preliminary research has also reported increased feelings of energy, reduced fatigue, and strong effects on improving focus, concentration, motivation to exercise and libido.


To examine the safety and non-habituating effects of Teacrine®, a nature-identical, chemically equivalent bioactive version of theacrine.


Sixty healthy men and women (mean ± SD age, height, weight: 22.55 ± 4.6 yr, 174.09 ± 12.4 cm, 77.47 ± 17.4 kg) were placed into one of three groups: placebo (P, n = 20), 200 mg Teacrine® (T2, n = 19) or 300 mg Teacrine® (T3, n = 21) and ingested their respective supplement once daily for eight weeks. Primary outcomes were fasting clinical safety markers (heart rate, blood pressure, lipid profiles, hematologic blood counts, biomarkers of liver/kidney/immune function) and energy, focus, concentration, anxiety, motivation to exercise, and POMS measured prior to daily dosing to ascertain potential tachyphylactic responses and discontinuation effects. Data were analyzed via ANOVA/ANCOVA and statistical significance was accepted at p ≤ 0.05.


All values for clinical safety markers fell within normal limits and no group × time interactions were noted. No habituation effects were noted as baseline values for energy, focus, concentration, anxiety, motivation to exercise, and POMS remained stable among groups. No serious adverse events were identified, and no differences in side effect profiles were detected between groups.


These findings support the clinical safety and non-habituating neuro-energetic effects of Teacrine® supplementation over eight weeks of daily use (up to 300 mg/day). Moreover, there was no evidence of a tachyphylactic response that is typical of neuroactive agents such as caffeine and other stimulants.


Authors’ Affiliations

Department of Exercise & Sports Science, Human Performance Lab, University of Mary Hardin-Baylor, Belton, USA


© Hayward et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.