The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility
© Parker et al. 2015
Published: 21 September 2015
Alpha-glycerylphosphorylcholine (Alpha-GPC) and caffeine supplementation have been shown to improve mental and physical performance. Alpha-GPC administration increases the release of the neurotransmitter acetylcholine and facilitates learning and memory. In athletes, Alpha-GPC supplementation prevents exercise-induced reductions in choline levels, increases endurance performance and growth hormone secretion. Caffeine has been shown to increase mental focus, acuity and athletic performance, however, contributes to a nervous or anxious feeling. The purpose of this study was to measure the acute effects of Alpha-GPC supplementation in comparison to caffeine or placebo on mood, cognitive function, and physiological performance.
Twenty participants [10 males, 10 females; 22.0 ± 3.4 years of age; height 171.9 ± 7.4 cm; weight 56.8 ± 8.6 kg] consumed 200 mg of Alpha-GPC (aGPC-L, AlphaSize®, Chemi Nutra, Austin, TX, USA), 400 mg of Alpha-GPC (aGPC-H), 200 mg of caffeine (CA), and a placebo (PL) in a randomized, double-blind, placebo-controlled, crossover design. Participants performed the following measurements 30 minutes after supplementation: visual analog scales (VAS) for six different moods, a serial subtraction test (SST), and tests for reaction time, hand-eye coordination, power, speed, and agility.
SST scores were 18.1% and 10.5% faster in the aGPC-L (6.19 ± 2.21 s) group compared to CA (7.32 ± 5.67 s) and PL (6.85 ± 2.52 s), respectively. Vertical Jump Peak Power was 8.5% higher in the aGPC-L (2,041.3 ± 547.2 W), 7.5% higher in the aGPC-H (2,023.1 ± 942.8 W) and 2.0% higher in the CA group (1,920.4 ± 689.6 W) in comparison to PL (1,881.9 ± 576.9 W).
The group consuming CA had significantly higher scores on the VAS for jitteriness compared to aGPC-H (p = 0.019), but not aGPC-L (p = 0.849) or PL (p = 0.086). There were no other statistically significant differences between supplement groups for any of the dependent variables.
Supported by Chemi Nutra, Austin, TX.
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