Botanical supplements with flavonoids possess the ability to reduce inflammatory markers such as CRP, IL-6, and TNF-α. Also, they could potentially help reduce sugar-induced weight gain and facilitate weight loss. Diafin is a non-stimulant, botanical, weight loss product created from a blend of standardized Free-B-ring flavonoids and flavans from two plant extracts isolated from the Scutellaria genus of plants and the Acacia genus of plants. Flavonoids, specifically from the Scutellaria genus, have been used previously for anti-inflammatory and cardiovascular applications, and have been suggested to inhibit eicosanoid generating enzymes such as phospholipase A2, cyclooxygenases, and lipoxygenases, while concomitantly reducing prostanoids and leukotrienes. However, the exact mechanism in which flavonoids induce an anti-inflammatory effect is unclear.