Powdered tart cherry supplementation seemed to attenuate the drop from pre-lift measures in 3-repetition summation of isokinetic flexion work (p = 0.21; d = 0.45, 0.28), extension work (p = 0.23; d = 0.45, 0.36), and all work (p = 0.15; d = 0.55, 0.37) through 60-min and 24-h of recovery compared to placebo as reported above by Cohen's d effect size, despite not being statistically significant. The overall MANOVA analysis revealed a significant Wilks' Lambda time (p < 0.001) interaction for all inflammatory markers, but no significant group × time pro-inflammatory (p = 0.30) and anti-inflammatory (p = 0.45) effects. Univariate measures for pro-inflammatory markers reported significant main time effects for TNF-α (p = 0.001), IL-1β (p = 0.30), IL-6 (p = 0.023), and IL-8 (p = 0.018). Univariate measures for anti-inflammatory markers reported significant main time effects for IL-4 (p = 0.001) and IL-7 (p = 0.033) with IL-13 trending toward significance (p = 0.055). No significant group × time effects were observed for any of the inflammatory markers, NT, or TBARS. Serum IL-1β levels were significantly lower in TC compared to P (p = 0.048). Delta changes were assessed at all three recovery time points from the pre-lift marker measures. The overall delta MANOVA analysis revealed a significant Wilks' Lambda pro-inflammatory interaction across time (p = 0.001) and an anti-inflammatory time interaction trending toward significance (p = 0.070), but no significant group × time pro-inflammatory (p = 0.44) or anti-inflammatory (p = 0.30) effects. TNF-α (p = 0.010), IFN-γ (p = 0.042), IL-1β (p = 0.031), IL-6 (p = 0.001), IL-8 (p = 0.025), IL-10 (p = 0.019), and NT (p = 0.018) demonstrated significant main effects on time, while IL-7 approached significance across time (p = 0.095). Serum IL-2 TC (p = 0.074) and IL-10 (p = 0.10) changes from pre-lift tended to be greater across the recovery time coupled with a tendency for IL-10 (p = 0.063) TC levels to also be greater compared to P. Contrarily, serum IFN-γ (p = 0.021) TC changes from pre-lift values were significantly smaller compared to P with specific differences at 24-h and 48-h post-lift.