Nineteen men and women (Mean ± SD; Age: 22.2 ± 2.2 yrs; Height: 174.8 ± 10.7 cm; Body mass: 71.9 ± 13.5 kg) performed a graded exercise treadmill test to volitional exhaustion to determine maximal oxygen consumption and peak velocity (PV). Treatment order was randomly assigned. Participants returned after 24-48 hours, and ingested two, 500mg capsules of either placebo (PL; 95% maltodextrin, 5% purple carrot and hibiscus for color) or pomegranate extract (PE; 1000 mg, TRUE Pomegranate Extract [NITRO2GRANIT™], Stiebs Nature Elevated, Madera, CA) with 6 oz. of water. Brachial artery blood flow was assessed using a GE logiq-e B-mode ultrasound (GE Healthcare, Wisconsin, USA) at baseline and 30 minutes post ingestion (30PI). In random order, subjects performed three treadmill runs to exhaustion at 90%, 100%, and 110%PV to determine critical velocity (CV), anaerobic running capacity (ARC), and time to exhaustion (TTE). Blood flow was assessed immediately after and 30 minutes after each exercise bout. A vitality scale was completed 30PI of PE or PL; a visual analog (pain) scale (VAS) was completed 30PI and immediately post exercise. After a 7-10 day washout period, participants repeated the same procedures, ingesting the opposite supplement. Separate mixed factorial ANOVAs were performed for blood flow, vessel diameter, CV, ARC, TTE, VAS, and vitality scale questions. Consent to publish the results was obtained from all participants.