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Table 3 Kidney function parameters before (Pre) and after 12 weeks (Post) of either creatine or placebo supplementation in resistance-trained individuals consuming a high-protein diet

From: Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet?

  Creatine (n = 12) Placebo (n = 14)  
Variable Pre Post Pre Post P (group x time interaction)
Albuminuria (mg/24 h) 19 (38) 15 (28) 8 (7) 4 (2) 0.99
Proteinuria (g/24 h) 0.14 (0.11) 0.14 (0.10) 0.10 (0.05) 0.10 (0.07) 0.83
Urinary potassium (mEq/24 h) 65 (24) 59 (22) 68 (24) 65 (19) 0.86
Urinary sodium (mEq/24 h) 231 (56) 226 (91) 195 (65) 191 (52) 0.99
Serum potassium (mEq/L) 4 (0.3) 4 (0.4) 5 (0.4) 4 (0.4) 0.26
Serum sodium (mEq/L) 141 (3) 141 (2) 142 (3) 141 (4) 0.53
Serum creatinine (mg/dL) 1.1 (0.1) 1.2 (0.2) 1.0 (0.1) 1.1 (0.1) 0.30
Serum urea (mg/dL) 41.7 (10.7) 39.2 (11.7) 33.3 (6.7) 33.4 (7.2) 0.63
  1. Data expressed as mean (standard deviation). There were no significant differences between groups at baseline. No significant within- or between-group differences were noted. Note: Conversion factors for units: serum creatinine in mg/dL to mol/L, ×88.4; serum urea in mg/dL to mmol/L, ×0.166; glomerular filtration rate in mL/min/1.73 m2 to mL/s/1.73 m2, ×0.01667.