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Table 2 Summary of studies investigating the effect of hypoxia on substrate utilisation during exercise matched for absolute intensity

From: Response: Commentary on the effects of hypoxia on energy substrate use during exercise

StudyParticipantsStudy designType of hypoxiaAltitude (m)Duration of exposureAbsolute substrate use (g.min− 1)Relative substrate use (%)
CHO oxidationFat oxidationCHO oxidationFat oxidation
Braun et al. [7]15 (females)30 min cycling at SL (50% SL VO2max) and hypoxia (65% altitude VO2max)TA430010 daysSL: 1.38 ± 0.08 CH:1.22 ± 0.09NMNMNM
Kelly and Basset [9]7 (males)60 min exercise at SL (69% SL VO2max) and altitude (78% altitude VO2max)NH2750180 minSL: 2.27 ± 0.57 AH: 2.30 ± 0.50SL: 0.46 ± 0.18 AH: 0.34 ± 0.21NMNM
Lundby and Van Hall [10] A8 (male = 6, female = 2)60 min cycling at SL (46% SL VO2max) and at altitude (54% SL VO2max)NH410070 minSL: 2.00 ± 0.20 AH: 2.50 ± 0.20SL: 0.30 ± 0.01 AH: 0.20 ± 0.01SL: 73.90 ± 2.00 AH: 86.20 ± 2.00SL: 26.10 ± 2.00 AH: 13.80 ± 2.00
Lundby and Van Hall [10] B8 (male = 6, female = 2)60 min cycling at SL (46% SL VO2max) and at altitude (59% altitude VO2max)TA410010 daysSL: 2.00 ± 0.20 CH: 2.30 ± 0.10SL: 0.30 ± 0.01 CH: 0.20 ± 0.01SL: 73.90 ± 2.00 CH: 82.20 ± 2.20SL: 26.10 ± 2.00 CH: 17.80 ± 2.20
Péronnet et al. [11]5 (males)80 min cycling at SL (54% SL max) and at altitude (77% altitude VO2max)HH4300110 minSL: 2.18 ± 0.11 AH:2.67 ± 0.10SL: 0.32 ± 0.08 AH: 0.10 ± 0.03SL: 75.30 ± 5.20 AH: 92.00 ± 2.10SL: 24.70 ± 5.20 AH: 8.00 ± 2.10
Van Hall et al. [12]6 (male = 5, female = 1)20 min cycling at SL (46% SL VO2max) and altitude (82% altitude VO2max)TA562063 daysSL: 2.22 ± 0.34 CH: 2.31 ± 0.14NMNMNM
  1. Values presented as mean ± SD
  2. HH hypobaric hypoxia, NH normobaric hypoxia, TA terrestrial altitude, SL sea level, AH acute hypoxia, CH chronic hypoxia, CHO carbohydrate, NM not measured