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Table 2 Summary of studies investigating the effect of hypoxia on substrate utilisation during exercise matched for absolute intensity

From: Response: Commentary on the effects of hypoxia on energy substrate use during exercise

Study

Participants

Study design

Type of hypoxia

Altitude (m)

Duration of exposure

Absolute substrate use (g.min− 1)

Relative substrate use (%)

CHO oxidation

Fat oxidation

CHO oxidation

Fat oxidation

Braun et al. [7]

15 (females)

30 min cycling at SL (50% SL VO2max) and hypoxia (65% altitude VO2max)

TA

4300

10 days

SL: 1.38 ± 0.08 CH:1.22 ± 0.09

NM

NM

NM

Kelly and Basset [9]

7 (males)

60 min exercise at SL (69% SL VO2max) and altitude (78% altitude VO2max)

NH

2750

180 min

SL: 2.27 ± 0.57 AH: 2.30 ± 0.50

SL: 0.46 ± 0.18 AH: 0.34 ± 0.21

NM

NM

Lundby and Van Hall [10] A

8 (male = 6, female = 2)

60 min cycling at SL (46% SL VO2max) and at altitude (54% SL VO2max)

NH

4100

70 min

SL: 2.00 ± 0.20 AH: 2.50 ± 0.20

SL: 0.30 ± 0.01 AH: 0.20 ± 0.01

SL: 73.90 ± 2.00 AH: 86.20 ± 2.00

SL: 26.10 ± 2.00 AH: 13.80 ± 2.00

Lundby and Van Hall [10] B

8 (male = 6, female = 2)

60 min cycling at SL (46% SL VO2max) and at altitude (59% altitude VO2max)

TA

4100

10 days

SL: 2.00 ± 0.20 CH: 2.30 ± 0.10

SL: 0.30 ± 0.01 CH: 0.20 ± 0.01

SL: 73.90 ± 2.00 CH: 82.20 ± 2.20

SL: 26.10 ± 2.00 CH: 17.80 ± 2.20

Péronnet et al. [11]

5 (males)

80 min cycling at SL (54% SL max) and at altitude (77% altitude VO2max)

HH

4300

110 min

SL: 2.18 ± 0.11 AH:2.67 ± 0.10

SL: 0.32 ± 0.08 AH: 0.10 ± 0.03

SL: 75.30 ± 5.20 AH: 92.00 ± 2.10

SL: 24.70 ± 5.20 AH: 8.00 ± 2.10

Van Hall et al. [12]

6 (male = 5, female = 1)

20 min cycling at SL (46% SL VO2max) and altitude (82% altitude VO2max)

TA

5620

63 days

SL: 2.22 ± 0.34 CH: 2.31 ± 0.14

NM

NM

NM

  1. Values presented as mean ± SD
  2. HH hypobaric hypoxia, NH normobaric hypoxia, TA terrestrial altitude, SL sea level, AH acute hypoxia, CH chronic hypoxia, CHO carbohydrate, NM not measured