From: Assessment of the FTO gene polymorphisms (rs1421085, rs17817449 and rs9939609) in exercise-trained men and women: the effects of a 4-week hypocaloric diet
In exercise-trained men and women, those carrying the risk C allele had a significantly higher fat mass and % body fat . This SNP is most likely risk variant showing the highest association with obesity [1, 11].
This SNP is associated with body mass index, weight and waist circumference .
This SNP is associated with diminished satiety .
Those who are AT or AA consumed between 125 and 280 kcal more each day than those with the protective TT genotype ; however, energy expenditure is not affected.