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Table 1 Studies investigating RER during exercise matched for relative intensities in hypoxia, compared with normoxia

From: The effects of environmental hypoxia on substrate utilisation during exercise: a meta-analysis

Study

Participants

Study design

Type of hypoxia

Altitude (m)

Duration of hypoxia

RER

Beidleman et al. (2002) [16]

8 (females)

Treadmill exercise at 70% relative VO2max until volitional exhaustion

HH

4300

180 min

SL: 0.89 ± 0.04

AH: 0.85 ± 0.03

Beidleman et al. (2003) A [45]

6 (male = 5, female = 1)

15 min cycling at 40% relative VO2max

HH

4300

70 min

SL: 0.97 ± 0.02

AH: 0.88 ± 0.01

Beidleman et al. (2003) B [45]

6 (male = 5, female = 1)

15 min cycling at 70% relative VO2max

HH

4300

70 min

SL: 1.02 ± 0.02

AH: 1.00 ± 0.03

Bouissou et al. (1987) [46]

6 (males)

60 min cycling at 60% relative VO2max

HH

3000

80 min

SL: 0.99 ± 0.02

AH: 1.00 ± 0.01

Braun et al. (2000) [11]

15 (females)

30 min cycling at 65% relative VO2max

TA

4300

10 days

SL: 0.97 ± 0.01

CH: 0.94 ± 0.01

Friedmann et al. (2004) [47]

11 (males)

60 min running at ~ 82% relative VO2max

NH

2500

120 min

SL: 0.93 ± 0.02

AH: 0.98 ± 0.07

Fulco et al. (2005) A [48]

16 (males)

20 min cycling at 48% relative VO2max

TA

4300

3 days

SL: 0.91 ± 0.01

CH: 0.81 ± 0.01

Fulco et al. (2005) B [48]

16 (males)

20 min cycling at 48% relative VO2max

TA

4300

10 days

SL: 0.91 ± 0.01

CH: 0.80 ± 0.01

Fulco et al. (2005) C [48]

16 (males)

20 min cycling at 68% relative VO2max

TA

4300

3 days

SL: 0.93 ± 0.01

CH: 0.85 ± 0.01

Fulco et al. (2005) D [48]

16 (males)

20 min cycling at 68% relative VO2max

TA

4300

10 days

SL: 0.93 ± 0.01

CH: 0.84 ± 0.01

Hopkins et al. (2003) A [49]

6 (male = 1, female = 5)

5 min cycling at 30% relative VO2max

NH

3850

25 min

SL: 0.82 ± 0.02

AH: 0.86 ± 0.03

Hopkins et al. (2003) B [49]

6 (male = 1, female = 5)

5 min cycling at 60% relative VO2max

NH

3850

25 min

SL: 0.95 ± 0.02

AH: 0.96 ± 0.03

Katayama et al. (2010) [3]

7 (males)

30 min cycling at 50% relative VO2max

HH

2000

100 min

SL: 0.90 ± 0.01

AH: 0.91 ± 0.02

Lundby and Van Hall (2002) A [22]

8 (male = 6, female = 2)

60 min cycling at 50% relative VO2max

NH

4100

70 min

SL: 0.91 ± 0.01

AH: 0.92 ± 0.02

Lundby and Van Hall (2002) B [22]

8 (male = 6, female = 2)

60 min cycling at 50% relative VO2max

TA

4100

28 days

SL: 0.91 ± 0.01

CH: 0.91 ± 0.01

Maher et al. (1974) A [50]

8 (males)

10 min cycling at 75% relative VO2max

TA

4300

44 h

SL: 0.99 ± 0.01

AH: 0.98 ± 0.01

Maher et al. (1974) B [50]

8 (males)

10 min cycling at 75% relative VO2max

TA

4300

12 days

SL: 0.99 ± 0.01

CH: 0.98 ± 0.01

Matu et al. (2017) A [6]

12 (males)

60 min walking at 50% relative VO2max

NH

2150

5 h

SL: 0.88 ± 0.04

AH: 0.85 ± 0.06

Matu et al. (2017) B [6]

12 (males)

60 min walking at 50% relative VO2max

NH

4300

5 h

SL: 0.88 ± 0.04

AH: 0.85 ± 0.06

Messier et al. (2017) [51]

20 (males)

60 min cycling at ~ 67% relative VO2max

TA

2150

150 min

SL: 0.92 ± 0.06

AH: 0.97 ± 0.05

Noordhof et al. (2013) A [52]

16 (male)

6 min cycling at 45% relative VO2max

HH

1500

30 min

SL: 0.89 ± 0.03

AH: 0.92 ± 0.02

Noordhof et al. (2013) B [52]

16 (male)

6 min cycling at 55% relative VO2max

HH

1500

30 min

SL: 0.91 ± 0.04

AH: 0.94 ± 0.04

Noordhof et al. (2013) C [52]

16 (male)

6 min cycling at 65% relative VO2max

HH

1500

30 min

SL: 0.94 ± 0.04

AH: 0.98 ± 0.04

O’Hara et al. (2017) A [5]

7 (males)

5 min cycling at ~ 62% relative VO2max

HH

3375

155 min

SL: 0.92 ± 0.04

AH: 0.83 ± 0.04

O’Hara et al. (2017) B [5]

7 (males)

105 min cycling at ~ 74% relative VO2max

HH

3375

155 min

SL: 0.92 ± 0.03

AH: 0.84 ± 0.05

Peronnet et al. (2006) [4]

5 (males)

80 min cycling at 77% relative VO2max

HH

4300

110 min

SL: 0.93 ± 0.01

AH: 0.97 ± 0.01

Wyss et al. (1990) [53]

7 (males)

30 min running at ~ 79% relative VO2max

NH

3500

60 min

SL: 0.90 ± 0.04

AH: 0.93 ± 0.04

Young et al. (1987) A [54]

12 (males)

30 min cycling at 75% relative VO2max (active between exercise tests)

TA

4300

<  24 h

SL: 0.84 ± 0.02

AH: 1.03 ± 0.01

Young et al. (1987) B [54]

12 (males)

30 min cycling at 75% relative VO2max (active between exercise tests)

TA

4300

13 days

SL: 0.84 ± 0.02

CH: 1.03 ± 0.06

Young et al. (1987) C [54]

12 (males)

30 min cycling at 75% relative VO2max (sedentary between exercise tests)

TA

4300

<  24 h

SL: 0.84 ± 0.01

AH: 1.05 ± 0.01

Young et al. (1987) D [54]

12 (males)

30 min cycling at 75% relative VO2max (sedentary between exercise tests)

TA

4300

13 days

SL: 0.84 ± 0.01

CH: 1.13 ± 0.05

  1. Values presented as mean ± SD. HH hypobaric hypoxia, NH normobaric hypoxia, TA terrestrial altitude, SL sea level, AH acute hypoxia, CH chronic hypoxia. A, B, C and D refer to the different trial arms of each study