Variable | Group | Number | Time (wk) | p-value | |||
---|---|---|---|---|---|---|---|
0 | 4 | 8 | |||||
ALP (U/L) | PLA | 27 | 76.8 ± 15.1 | 66.4 ± 12.9 | 71.2 ± 13.4 | Group | 0.24 |
PWS | 27 | 87.2 ± 24.7 | 72.3 ± 19.0 | 78.4 ± 24.9 | Time | <0.001 | |
PWS + S | 26 | 76.4 ± 22.8 | 68.1 ± 17.3 | 74.4 ± 19.6 | G x T | 0.25 | |
ALT (U/L) | PLA | 27 | 25.3 ± 10.0 | 25.0 ± 22.4 | 24.6 ± 13.0 | Group | 0.74 |
PWS | 27 | 25.1 ± 10.1 | 26.9 ± 16.0 | 30.9 ± 17.9 | Time | 0.73 | |
PWS + S | 26 | 26.6 ± 23.0 | 28.6 ± 20.8 | 26.0 ± 12.2 | G x T | 0.55 | |
AST (U/L) | PLA | 27 | 29.1 ± 11.0 | 27.6 ± 17.7 | 27.1 ± 9.8 | Group | 0.47 |
PWS | 27 | 28.8 ± 9.7 | 31.6 ± 26.1 | 33.1 ± 19.7 | Time | 0.96 | |
PWS + S | 26 | 28.4 ± 15.1 | 28.4 ± 10.3 | 27.3 ± 8.5 | G x T | 0.76 | |
CK (U/L) | PLA | 27 | 310.0 ± 217.2 | 263.1 ± 214.4 | 215.5 ± 115.1 | Group | 0.34 |
PWS | 27 | 297.5 ± 160.4 | 256.9 ± 203.7 | 336.1 ± 242.0 | Time | 0.79 | |
PWS + S | 26 | 261.2 ± 130.0 | 324.1 ± 232.2 | 274.8 ± 172.3 | G x T | 0.86 | |
LDH (U/L) | PLA | 27 | 164.2 ± 36.2 | 153.5 ± 33.9 | 159.4 ± 29.5 | Group | 0.90 |
PWS | 27 | 157.7 ± 24.2 | 160.7 ± 37.6 | 162.8 ± 24.3 | Time | 0.19 | |
PWS + S | 26 | 158.8 ± 32.1 | 152.5 ± 24.3 | 160.4 ± 23.6 | G x T | 0.44 | |
BUN (mg/dl) | PLA | 27 | 14.9 ± 4.9 b | 12.3 ± 6.7 | 16.2 ± 6.8 | Group | 0.62 |
PWS | 27 | 12.0 ± 4.0 c | 12.3 ± 5.8 | 16.1 ± 5.3 | Time | <0.001 | |
PWS + S | 26 | 13.6 ± 4.9 | 12.6 ± 6.6 | 16.5 ± 5.0 | G x T | 0.55 | |
Creatinine (mg/dl) | PLA | 27 | 1.15 ± 0.44 | 0.72 ± 0.47 | 0.85 ± 0.36a | Group | 0.27 |
PWS | 27 | 1.08 ± 0.41 | 0.75 ± 0.38 | 0.95 ± 0.31 | Time | <0.001 | |
PWS + S | 26 | 1.13 ± 0.51 | 0.82 ± 0.43 | 1.05 ± 0.28c | G x T | 0.78 | |
BUN:Creatinine | PLA | 27 | 15.7 ± 9.6 | 24.7 ± 19.1 | 26.5 ± 23.4 | Group | 0.20 |
PWS | 27 | 12.7 ± 6.8 | 22.7 ± 17.3 | 20.4 ± 15.0 | Time | 0.002 | |
PWS + S | 26 | 15.3 ± 10.9 | 20.9 ± 15.1 | 17.9 ± 12.6 | G x T | 0.63 |