Twelve weeks supplementation with an extended-release caffeine and ATP-enhancing supplement may improve body composition without affecting hematology in resistance-trained men

Joy, Jordan M.; Vogel, Roxanne M.; Moon, Jordan R.; Falcone, Paul H.; Mosman, Matt M.; Kim, Michael P.

doi:10.1186/s12970-016-0136-9

Journal of the International Society of Sports Nutrition

Table 5 Blood Chemistry Data. Data are presented as mean ± standard deviation

From: Twelve weeks supplementation with an extended-release caffeine and ATP-enhancing supplement may improve body composition without affecting hematology in resistance-trained men

Variable	Treatment	PRE	Week 8	POST	Reference Interval	p
Serum Glucose (mg/dL)	PLA	90.5 ± 11.0	89.3 ± 3.6	90.2 ± 5.4	65–99	0.84
Serum Glucose (mg/dL)	TRT	88.8 ± 6.1	89.6 ± 7.0	90.0 ± 6.8	65–99	0.84
BUN (mg/dL)	PLA	17.3 ± 4.9	17.8 ± 3.9	17.5 ± 4.2	6–20	0.98
BUN (mg/dL)	TRT	15.1 ± 3.2	15.7 ± 3.1	15.7 ± 3.5	6–20	0.98
Serum Creatinine (mg/dL)	PLA	0.97 ± 0.12	1.04 ± 0.12^a	1.13 ± 0.17*^ab	0.76–1.27	0.001
Serum Creatinine (mg/dL)	TRT	1.05 ± 0.15	1.10 ± 0.11	1.05 ± 0.12*^‡	0.76–1.27	0.001
eGFR (mL/min/1.73)	PLA	105.6 ± 12.9	98.7 ± 12.5^a	91.0 ± 14.9^a	>59	0.01
eGFR (mL/min/1.73)	TRT	101.0 ± 15.8	95.2 ± 11.1	100.3 ± 12.9*^‡	>59	0.01
BUN/Creatinine Ratio	PLA	18.0 ± 5.9	17.3 ± 4.0	15.8 ± 4.4	8–19	0.33
BUN/Creatinine Ratio	TRT	14.4 ± 3.1	14.3 ± 1.8	15.0 ± 3.7	8–19	0.33
Serum Sodium (mmol/L)	PLA	138.8 ± 1.8	139.6 ± 1.3	140.4 ± 2.1	134–144	0.43
Serum Sodium (mmol/L)	TRT	138.9 ± 1.7	138.7 ± 1.3	140.4 ± 1.3	134–144	0.43
Serum Potassium (mmol/L)	PLA	4.4 ± 0.4	4.5 ± 0.5	4.3 ± 0.3	3.5–5.2	0.06
Serum Potassium (mmol/L)	TRT	4.4 ± 0.3	4.4 ± 0.3	4.6 ± 0.3	3.5–5.2	0.06
Serum Chloride (mmol/L)	PLA	102.1 ± 1.6	101.0 ± 1.4	102.4 ± 2.2	97–108	0.92
Serum Chloride (mmol/L)	TRT	101.7 ± 1.8	100.7 ± 2.1	102.3 ± 1.6	97–108	0.92
Carbon Dioxide (mmol/L)	PLA	23.6 ± 2.4	22.1 ± 1.5	22.5 ± 1.5	19–28	0.24
Carbon Dioxide (mmol/L)	TRT	23.1 ± 2.4	21.0 ± 1.2	22.8 ± 1.4	19–28	0.24
Serum Calcium (mg/dL)	PLA	9.4 ± 0.4	9.4 ± 0.3	9.3 ± 0.3	8.7–10.2	0.45
Serum Calcium (mg/dL)	TRT	9.6 ± 0.4	9.5 ± 0.3	9.4 ± 0.4	8.7–10.2	0.45
Serum Protein (g/dL)	PLA	7.1 ± 0.3	6.9 ± 0.3	6.9 ± 0.3	6.0–8.5	0.58
Serum Protein (g/dL)	TRT	7.2 ± 0.3	6.9 ± 0.2	6.9 ± 0.3	6.0–8.5	0.58
Serum Albumin (g/dL)	PLA	4.4 ± 0.3	4.6 ± 0.2	4.6 ± 0.2	3.5–5.5	0.65
Serum Albumin (g/dL)	TRT	4.5 ± 0.2	4.6 ± 0.2	4.6 ± 0.2	3.5–5.5	0.65
Globulin (g/dL)	PLA	2.6 ± 0.2	2.3 ± 0.2	2.3 ± 0.2	1.5–4.5	0.83
Globulin (g/dL)	TRT	2.7 ± 0.2	2.3 ± 0.3	2.3 ± 0.3	1.5–4.5	0.83
Albumin:Globulin Ratio	PLA	1.7 ± 0.2	2.0 ± 0.2	2.0 ± 0.3	1.1–2.5	0.76
Albumin:Globulin Ratio	TRT	1.7 ± 0.2	2.0 ± 0.3	2.1 ± 0.3	1.1–2.5	0.76
Bilirubin (mg/dl)	PLA	0.6 ± 0.2	0.6 ± 0.2	0.6 ± 0.2	0.0–1.2	0.06
Bilirubin (mg/dl)	TRT	0.6 ± 0.3	0.7 ± 0.4	0.5 ± 0.2	0.0–1.2	0.06
Alkaline Phosphatase (IU/L)	PLA	76.4 ± 13.8	81.3 ± 14.6	79.9 ± 16.1	39–117	0.53
Alkaline Phosphatase (IU/L)	TRT	70.5 ± 20.8	79.5 ± 27.2	77.8 ± 23.4	39–117	0.53
AST (IU/L)	PLA	25.5 ± 7.8	26.9 ± 7.4	25.8 ± 8.9	0–40	0.81
AST (IU/L)	TRT	25.1 ± 7.5	28.9 ± 11.6	27.2 ± 12.7	0–40	0.81
ALT (IU/L)	PLA	23.7 ± 4.9	24.3 ± 7.0	22.5 ± 6.3	0–44	0.48
ALT (IU/L)	TRT	23.5 ± 11.1	23.3 ± 8.6	26.5 ± 12.2	0–44	0.48

*indicates significantly different from PLA at the corresponding time point. ‡ indicates significantly different from PLA at week 8. The p-value is derived from an ANOVA and representative of a main effect for group by time. Significant within-group time differences are indicated by ^a(different from pre) and ^b(different from week 8) for variables with a significant group x time interaction

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