Table 3 Hepatorenal and blood cell characteristics of Study 2 participants

 ALPS

PLA

11.2 ± 14.6

10.5 ± 10.7

12.4 ± 10.9

Group

0.44

 (U/L)

CrM

11.4 ± 9.5

12.0 ± 10.4

11.0 ± 7.8

Time

0.36

CrN-Low

15.5 ± 11.4

16.2 ± 11.9

19.5 ± 15.9

Group × Time

0.85

CrN-High

12.0 ± 7.1

13.6 ± 6.1

14.3 ± 11.7

 ALT

PLA

27.2 ± 8.6

30.2 ± 13.8

32.1 ± 30.6

Group

0.24

 (U/L)

CrM

28.9 ± 16.6

25.1 ± 10.0

32.7 ± 22.9

Time

0.06

CrN-Low

21.3 ± 6.7

19.9 ± 4.4

22.4 ± 6.7

Group × Time

0.70

CrN-High

28.7 ± 13.2

30.0 ± 15.7

36.8 ± 23.2

 AST

PLA

31.2 ± 13.3

30.1 ± 11.6

29.5 ± 13.4

Group

0.90

 (U/L)

CrM

28.3 ± 10.2

26.4 ± 7.7

32.5 ± 12.3

Time

0.56

CrN-Low

26.0 ± 7.0

30.6 ± 25.3

26.0 ± 6.0

Group × Time

0.47

CrN-High

26.4 ± 5.9

28.7 ± 7.0

32.0 ± 7.6

 CK

PLA

252 ± 128

294 ± 399

206 ± 161

Group

0.79

 (U/L)

CrM

285 ± 169

345 ± 319

409 ± 373

Time

0.35

CrN-Low

283 ± 169

480 ± 987

243 ± 136

Group × Time

0.56

CrN-High

284 ± 171

349 ± 203

424 ± 287

 LDH

PLA

226 ± 180

167 ± 29

158 ± 34

Group

0.93

 (U/L)

CrM

185 ± 62

172 ± 39

184 ± 48

Time

0.20

CrN-Low

175 ± 50

173 ± 41

166 ± 29

Group × Time

0.23

CrN-High

173 ± 29

176 ± 30

182 ± 39

 BUN

PLA

16.3 ± 3.6

15.6 ± 5.2

15.7 ± 4.9

Group

0.64

 (mg/dl)

CrM

15.3 ± 5.5

15.2 ± 4.9

16.3 ± 6.1

Time

0.48

CrN-Low

14.9 ± 3.8

13.3 ± 3.9

13.5 ± 4.6

Group × Time

0.64

CrN-High

14.6 ± 3.2

14.8 ± 2.7

15.7 ± 5.8

 Creatinine

PLA

1.18 ± 0.26

1.19 ± 0.33

1.15 ± 0.27

Group

0.97

 (mg/dl)

CrM

1.15 ± 0.46

1.26 ± 0.36

1.23 ± 0.39

Time

0.001

CrN-Low

1.09 ± 0.25

1.21 ± 0.31

1.23 ± 0.31

Group × Time

0.12

CrN-High

1.12 ± 0.18

1.15 ± 0.23

1.20 ± 0.23

 BUN: Creatinine

PLA

14.2 ± 3.7

13.9 ± 6.8

13.6 ± 3.1

Group

0.78

 (mg/dl)

CrM

13.7 ± 3.6

12.8 ± 5.3

14.0 ± 6.1

Time

0.07

CrN-Low

14.1 ± 4.2

11.4 ± 3.8

11.3 ± 3.4

Group × Time

0.13

CrN-High

13.3 ± 3.8

13.3 ± 3.3

13.4 ± 4.8

 MCV

PLA

92.2 ± 3.1

91.7 ± 3.7

91.6 ± 3.8

Group

0.79

 (fL)

CrM

93.0 ± 3.9

93.7 ± 3.9

93.6 ± 4.7

Time

0.47

CrN-Low

91.7 ± 3.8

91.8 ± 4.0

92.3 ± 4.2

Group × Time

0.49

CrN-High

93.3 ± 3.0

93.4 ± 3.1

88.7 ± 17.7

 MCH

PLA

30.4 ± 1.7

30.5 ± 1.3

31.0 ± 2.3

Group

0.45

 (pg/cell)

CrM

30.6 ± 1.4

31.2 ± 1.5

31.0 ± 2.6

Time

0.23

CrN-Low

30.6 ± 1.7

31.6 ± 2.1

31.3 ± 2.2

Group × Time

0.92

CrN-High

31.2 ± 0.9

31.3 ± 1.4

31.5 ± 1.2

 MCHC

PLA

32.9 ± 1.2

33.3 ± 1.7

33.8 ± 1.8

Group

0.40

 (g/dl)

CrM

32.9 ± 0.7

33.3 ± 1.5

33.1 ± 1.9

Time

0.53

CrN-Low

33.3 ± 0.8

34.5 ± 3.4

33.9 ± 1.7

Group × Time

0.66

CrN-High

33.5 ± 0.7

33.5 ± 1.6

32.2 ± 6.0

 RBCDW

PLA

13.2 ± 0.5

13.1 ± 0.9

13.1 ± 0.3

Group

0.02

 (%)

CrM

13.5 ± 0.9

13.7 ± 0.9

13.9 ± 0.8

Time

0.11

CrN-Low

13.6 ± 0.6

13.4 ± 0.6

13.5 ± 0.7

Group × Time

0.66

CrN-High

12.8 ± 0.6

13.2 ± 0.6

13.1 ± 0.4

 Platelet Count

PLA

206 ± 36

188 ± 32

208 ± 70

Group

0.35

 (x10³/μL)

CrM

234 ± 57

226 ± 91

255 ± 51

Time

0.56

CrN-Low

218 ± 69

183 ± 50

194 ± 68

Group × Time

0.39

CrN-High

220 ± 61

412 ± 713

224 ± 59

 WBC

PLA

6.2 ± 1.7

5.3 ± 1.5

6.2 ± 1.1

Group

0.72

 (x10³/μL)

CrM

6.0 ± 1.7

6.6 ± 1.3

6.4 ± 1.3

Time

0.58

CrN-Low

6.2 ± 1.6

5.9 ± 1.8

5.4 ± 1.3

Group × Time

0.18

CrN-High

5.9 ± 1.4

5.5 ± 1.6

6.1 ± 1.6

 RBC

PLA

5.2 ± 0.8

5.01 ± 0.83

4.8 ± 0.6

Group

0.25

 (x10⁶/μL)

CrM

5.3 ± 0.6

5.60 ± 0.97

5.1 ± 0.8

Time

0.09

CrN-Low

5.0 ± 0.5

5.11 ± 0.95

4.9 ± 0.7

Group × Time

0.65

CrN-High

5.5 ± 0.8

5.08 ± 0.51

5.1 ± 0.5

 Hematocrit

PLA

47.7 ± 7.1

46.0 ± 8.2

44.0 ± 4.5

Group

0.16

 (%)

CrM

49.5 ± 6.7

52.5 ± 9.7

47.6 ± 8.4

Time

0.51

CrN-Low

46.2 ± 5.5

47.1 ± 10.3

44.8 ± 7.1

Group × Time

0.44

CrN-High

51.2 ± 7.8

47.5 ± 5.2

51.7 ± 15.4

 Hemoglobin

PLA

15.7 ± 2.5

15.3 ± 2.7

14.8 ± 1.2

Group

0.17

 (g/dl)

CrM

16.3 ± 2.1

20.1 ± 10.2

15.7 ± 2.8

Time

0.63

CrN-Low

15.4 ± 2.1

16.1 ± 3.1

15.2 ± 2.3

Group × Time

0.19

CrN-High

17.2 ± 2.7

15.9 ± 1.4

18.7 ± 9.5