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Table 7 Clinical whole blood safety markers, part I

From: Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use

Variable T1 T2 T3 Time*group Time*group*gender
White blood cells (103 cells/μL)
 PLA 6.0 ± 1.8 5.9 ± 1.7 6.2 ± 1.6 Time p = 0.52 G*T*Ge p = 0.18
 LD 6.5 ± 1.5 6.3 ± 1.5 6.4 ± 1.5 G*T p = 0.52
 HD 6.9 ± 1.5 6.5 ± 1.2 6.4 ± 1.8
RBC (106 cells/μl)
 PLA 4.4 ± 0.4 4.4 ± 0.5 4.5 ± 0.4 Time p = 0.12 G*T*Ge p = 0.10
 LD 4.8 ± 0.4 4.7 ± 0.4 4.8 ± 0.4 G*T p = 0.36
 HD 4.8 ± 0.4 4.8 ± 0.5 4.8 ± 0.5
Hemoglobin (g/dL)
 PLA 13.8 ± 1.0 13.7 ± 1.5 13.9 ± 1.3 Time p = 0.56 G*T*Ge p= 0.006
 LD 14.4 ± 1.1 14.3 ± 1.1 14.5 ± 1.1 G*T p = 0.78
 HD 14.2 ± 1.4 14.1 ± 1.3 14.1 ± 1.4
Hematocrit (%)
 PLA 41 ± 3 41 ± 5 42 ± 3 Time p = 0.23 G*T*Ge p= 0.049
 LD 43 ± 4 43 ± 3 44 ± 3 G*T p = 0.85
 HD 43 ± 4 43 ± 4 43 ± 4
Platelet Count (103 particles/μL)
 PLA 160 ± 46 191 ± 50 204 ± 89 Time p= 0.005 G*T*Ge p = 0.16
 LD 148 ± 61 176 ± 35 212 ± 71 G*T p = 0.77
 HD 191 ± 40 216 ± 51 227 ± 41
Neutrophils (103 cells/μL)
 PLA 3123 ± 843 3441 ± 1440 3679 ± 1443 Time p = 0.67 G*T*Ge p = 0.12
 LD 3423 ± 920 3196 ± 862 3444 ± 881 G*T p = 0.28
 HD 3631 ± 1417 3570 ± 921 3452 ± 1423
Lymphocytes (103 cells/μL)
 PLA 1881 ± 543 1908 ± 479 1928 ± 492 Time p = 0.20 G*T*Ge p = 0.50
 LD 2393 ± 698 2325 ± 738 2232 ± 681 G*T p = 0.13
 HD 2624 ± 664 2200 ± 425 2384 ± 761
Monocytes (103 cells/μL)
 PLA 426 ± 123 414 ± 150 412 ± 131 Time p = 0.97 G*T*Ge p = 0.07
 LD 467 ± 149 498 ± 131 456 ± 156 G*T p = 0.65
 HD 424 ± 184 399 ± 106 427 ± 123
Eosinophils (103 cells/μL)
 PLA 157 ± 109 187 ± 125 166 ± 115 Time p = 0.62 G*T*Ge p= 0.002
 LD 187 ± 108 187 ± 102 189 ± 112 G*T p= 0.041
 HD 225 ± 130 164 ± 87 181 ± 83
Basophils (103 cells/μL)
 PLA 27 ± 12 24 ± 11 25 ± 12 Time p = 0.07 G*T*Ge p = 0.28
 LD 30 ± 14 36 ± 19 25 ± 11 G*T p = 0.21
 HD 32 ± 18 43 ± 23 33 ± 20
  1. Abbreviations: PLA Placebo, LD Theacrine Low Dose, HD Theacrine High Dose, G Group, T Time, Ge Gender
  2. Symbols: , increase from corresponding T2 value within the female PLA group (p < 0.05); , different from corresponding T1 value (p < 0.05). Items in bold indicate a significant effect (p < 0.05) was observed