Baseline | Wk 3 | Wk 6 | Wk 9 | Effect | |
---|---|---|---|---|---|
Bone Absorption Biomarkers | |||||
BAP, μg/L | T | ||||
Group (n = 71) | 27.6 ± 1.6 | 36.6 ± 1.9† | 39.1 ± 1.9† | 38.8 ± 2.0† | |
White (n = 45) | 26.2 ± 2.3 | 33.9 ± 2.4 | 37.1 ± 2.3 | 36.9 ± 2.3 | |
Non-white (n = 26) | 29.9 ± 3.0 | 41.1 ± 3.1 | 42.9 ± 3.1 | 42.0 ± 3.0 | |
PINP, μg/L | T | ||||
Group (n = 71) | 62.4 ± 3.7 | 75.1 ± 3.8† | 78.7 ± 3.8† | 78.7 ± 3.7† | |
White (n = 45) | 62.9 ± 4.5 | 72.5 ± 4.6 | 75.1 ± 4.5 | 77.7 ± 4.5 | |
Non-white (n = 26) | 61.9 ± 5.9 | 77.7 ± 6.0 | 82.4 ± 6.0 | 79.8 ± 5.9 | |
Bone Resorption Biomarkers | |||||
TRAP, U/L | T | ||||
Group (n = 71) | 4.3 ± 0.2 | 4.6 ± 0.2 | 4.8 ± 0.2† | 5.0 ± 0.2†, ‡ | |
White (n = 45) | 4.2 ± 0.2 | 4.7 ± 0.2 | 4.8 ± 0.2 | 5.0 ± 0.2 | |
Non-white (n = 26) | 4.5 ± 0.3 | 4.4 ± 0.3 | 4.8 ± 0.3 | 5.0 ± 0.3 | |
CTx, μg/L | T | ||||
Group (n = 71) | 1.1 ± 0.1 | 1.0 ± 0.1 | 1.2 ± 0.1 | 1.2 ± 0.1‡ | |
White (n = 45) | 1.2 ± 0.1 | 1.1 ± 0.1 | 1.1 ± 0.1 | 1.2 ± 0.1 | |
Non-white (n = 26) | 1.0 ± 0.1 | 1.0 ± 0.1 | 1.2 ± 0.1 | 1.1 ± 0.1 |