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Table 4 Phosphorylated levels of Akt/mTOR pathway intermediates for WP and CHO.

From: Ingestion of 10 grams of whey protein prior to a single bout of resistance exercise does not augment Akt/mTOR pathway signaling compared to carbohydrate

Variable Time Point WP CHO p-value
IRS-1 Baseline 15.68 ± 9.6 19.52 ± 6.4 Supplement (S) = 0.88
  15 min post-exercise 29.04 ± 6.6† 22.28 ± 11.2 Test (T) = 0.04†#
  120 min post-exercise 25.40 ± 6.0 19.65 ± 9.2 S × T = 0.44
Akt Baseline 5.04 ± 1.9 6.88 ± 1.1 Supplement (S) = 0.21
  15 min post-exercise 6.04 ± 2.6 5.61 ± 4.1 Test (T) = 0.35
  120 min post-exercise 4.78 ± 1.4 4.58 ± 2.1 S × T = 0.82
mTOR Baseline 3.34 ± 0.34 3.62 ± 0.19 Supplement (S) = 0.93
  15 min post-exercise 3.75 ± 0.62 3.66 ± 0.27 Test (T) = 0.002†
  120 min post-exercise 3.33 ± 0.19 3.52 ± 0.28 S × T = 0.34
P70S6K Baseline 8.51 ± 3.2 10.41 ± 3.2 Supplement (S) = 0.96
  15 min post-exercise 14.14 ± 6.6 11.18 ± 2.9 Test (T) = 0.04
  120 min post-exercise 13.32 ± 6.1 11.24 ± 5.0 S × T = 0.74
4E-BP1 Baseline 4.30 ± 2.4 5.33 ± 1.7 Supplement (S) = 0.28
  15 min post-exercise 2.66 ± 1.3† 2.28 ± 1.0 Test (T) = 0.001†
  120 min post-exercise 4.07 ± 1.9# 4.90 ± 1.8 S × T = 0.64
  1. Data are means ± standard deviations.
  2. p70S6K, eIF4E-BP1, AKT and IRS-1 are expressed as U/ml/mg.
  3. mTOR is expressed as absorbance units at 450 nm/mg.
  4. † represents significant difference from baseline at 15 min post-exercise.
  5. # represents significant difference from baseline at 120 min post-exercise.