Table 1 Hemodynamic Clinical Safety Markers
Time | 0.5 mg | Placebo | 5.0 mg | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | -60 | 0 | 15 | 120 | -60 | 0 | 15 | 120 | -60 | 0 | 15 | 120 |
Heart Rate (bpm) | 67 ±11.9 | 67 ±10.7 | 84 ±9.9 | 63 ±8.0 | 59 ±10.6 | 60 ±8.4 | 77 ±9.2 | 61 ±10.5 | 68 ±10.1 | 64 ±8.4 | 78 ±9.4 | 60 ±7.2 |
SBP (mmHg) | 114 ±7.8 | 111 ±5.8 | 118 ±10.6 | 110 ±10.4 | 114 ±6.4 | 114 ±7.9 | 115 ±7.6 | 111 ±8.1 | 110 ±7.4 | 113 ±8.3 | 117 ±6.9 | 112 ±8.4 |
DBP (mmHg) | 77 ±4.8 | 70 ±6.7 | 73 ±7.0 | 69 ±11.9 | 70 ±5.6 | 72 ±8.2 | 73 ±6.4 | 73 ±9.5 | 76 ±4.7 | 76 ±5.8 | 78 ±7.3 | 73 ±6.3 |