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Table 5 Subjects reporting complete loss of knee pain on stepmill test

From: Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers

Visit

UC-II

Placebo

No. of pain free subjects (%)

Continuity of pain loss#

P value (Binomial test)

No. of pain free subjects (%)

Continuity of pain loss#

P value (Binomial test)

Baseline

0.0 (0)

0

NA

0.0 (0)

0

NA

Day 7

0.0 (0)

0

NA

0.0 (0)

0

NA

Day 30

1.0 (4)

1N

0.5

0.0 (0)

0

NA

Day 60

3.0 (13)

1R, 2N

0.125

0.0 (0)

0

NA

Day 90

3.0 (13)

2R, 1N

0.125

1 (5)

1N

0.5

Day 120

5.0 (21)

3R, 2N

0.031

1 (5)

1R

0.5

  1. Values denote number of subjects while parenthesis provides the percent of total subjects who did not have any pain on stepmill. Continuity indicates the number of subjects in whom the absence of pain was maintained across visits. Significant at p ≤ 0.05 based on independent binomial testing of each visit using the null hypothesis that the probability of a subject experiencing no joint pain is equal to zero. There was no statistical difference between groups. #R Repeat subject (i.e. same subject who reported no pain in previous visit), N New subject who reports no pain for the first time.