|
Variable
|
METABO
|
Placebo
|
P
|
|---|
|
n = 27
|
n = 18
|
Value1
|
|---|
|
(Baseline) Pre-intervention
|
Mid point
|
End of study
|
(Baseline) Pre-intervention
|
Mid point
|
End of study
| |
|---|
| |
(Week 0)
|
(Week 4)
|
(Week 8)
|
(Week 0)
|
(Week 4)
|
(Week 8)
| |
|---|
|
Energy (kcal/d)
|
1831 ± 491
|
1889 ± 428
|
1912 ± 423
|
1764 ± 482
|
1913 ± 432
|
1917 ± 479
|
0.48, 0.41
|
|
Carbohydrate (g/d)
|
206 ± 78
|
188 ± 58
|
188 ± 57
|
215 ± 94
|
191 ± 58
|
202 ± 61
|
0.94, 0.80
|
|
Carbohydrate (%)
|
46 ± 14
|
39 ± 6
|
39 ± 5
|
48 ± 15
|
40 ± 6
|
42 ± 5
|
0.70, 0.90
|
|
Fat (g/d)
|
54 ± 20
|
56 ± 17
|
57 ± 15
|
52 ± 23
|
57 ± 13
|
56 ± 13
|
0.87, 0.85
|
|
Fat (%)
|
26 ± 7
|
27 ± 4
|
27 ± 4
|
27 ± 10
|
27 ± 4
|
27 ± 4
|
0.98, 0.79
|
|
Protein (g/d)
|
130 ± 66
|
158 ± 43
|
162 ± 47
|
110 ± 50
|
161 ± 47
|
150 ± 50
|
0.77, 0.66
|
|
Protein (%)
|
28 ± 12
|
34 ± 8
|
34 ± 7
|
26 ± 13
|
34 ± 7
|
31 ± 6
|
0.52, 0.99
|
- Values are mean ± SD.
- 1P values are for the differences between the two groups, METABO versus placebo at week 4 and week 8, respectively. No significant between group differences at week 4 or week 8 time points were noted using ANCOVA (where the week 0 time points were used as the covariate). Target dietary intake was provided to each subject after baseline 3-day food records (pre-intervention) using the Mifflin-St. Jeor equation plus an activity factor of 1.2 minus 500 kcal/day, with a macronutrient ratio of 40% carbohydrate, 30% fat and 30% protein.
