Volume 8 Supplement 1

Proceedings of the Eighth International Society of Sports Nutrition (ISSN) Conference and Expo

Open Access

The effect of alpha lipoic acid ingestion on glucose uptake in healthy males

Journal of the International Society of Sports Nutrition20118(Suppl 1):P32

DOI: 10.1186/1550-2783-8-S1-P32

Published: 7 November 2011

Background

There are reports that indicate dietary alpha lipoic acid (ALA) supplementation enhances glucose uptake. The research was done with animal models and diabetic humans, but the effects of ALA supplementation on glucose uptake in healthy humans are unknown. The present study was designed to test the hypothesis that acute ingestion of ALA would enhance glucose uptake in healthy male subjects.

Methods

Thirteen healthy, male volunteers (age, 22.2 ± 2.8 years; body mass, 76.5 ± 11.1 kg; mean ± SD) were recruited to participate in a randomized single-blind crossover study. Subjects were administered two fasting oral glucose tolerance tests (OGTT) to clarify if ALA enhanced their glucose uptake. Subsequently, on 2 different occasions with at least one intervening week, subjects cycled at 75% of VO2max for an hour and then completed three to four 5-min bouts at 90% of VO2max with 5 min of active recovery between bouts. Following exercise, subjects were supplemented with either 1g/kg bw of carbohydrate solution, or 1g/kg bw of carbohydrate and 4mg/kg bw of ALA every hour for 4 h post exercise. During this recovery period, venous blood samples were obtained and immediately assayed for plasma glucose concentration using an automated glucose analyzer. Serum insulin values were subsequently assayed using the IMMULITE 2000 immunoassay system. Both absolute concentrations and the areas under the curve for the glucose and insulin concentrations were compared between the ALA and placebo trials.

Results

Regardless of treatment, the AUC0-120min for glucose (12.7±1.6mmol/L·h-1 for placebo; 13.2±1.8 mmol/L·h-1 for ALA) and the AUC0-120min for insulin (500±130pmol/L·h-1 for placebo; 516±1712 pmol/L·h-1 for ALA) remained unchanged during the OGTT (P>0.05). However during the four hours post exercise, there was a main effect for treatment; glucose values were significantly higher in the ALA condition (7.1±1.8mmol/L for ALA vs. 6.5±1.8mmol/L for placebo; P<0.05). Insulin values were also significantly higher at 180 minutes post exercise in the ALA condition (656±359 pmol/L) compared to placebo (472±206 pmol/L; P<0.05).

Conclusion

In contrast with earlier reports of the effects of ALA in animals and diabetic humans, this study concludes that enhancement of glucose uptake does not occur in healthy males. The ALA treatment interaction causing higher insulin and glucose values during recovery from exhaustive exercise should be further studied.

Authors’ Affiliations

(1)
School of Kinesiology and Health Science, York University
(2)
Faculty of Physical Education & Health, University of Toronto

Copyright

© Mandic et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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