Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women

Table 4 Metabolic variables of METABO and placebo groups from week 0 through week 8

Blood lipid		METABO				Placebo			P
		n = 27				n = 18			Value¹
	Baseline	Mid point	End of study	%	Baseline	Mid point	End of study	%
	(Week 0)	(Week 4)	(Week 8)	Change	(Week 0)	(Week 4)	(Week 8)	Change
Cholesterol, (mg/dL)	178.33 ± 26.49	NP	173.30 ± 30.25	-2.8	175.78 ± 31.45	NP	176.50 ± 31.14	0.4	0.3
HDL (mg/dL)	48.44 ± 12.47	NP	48.56 ± 15.26	0.2	50.28 ± 10.86	NP	48.94 ± 12.06	-2.7	0.49
LDL (mg/dL)	103.96 ± 26.04	NP	103.00 ± 30.92	-0.9	100.94 ± 28.53	NP	100.78 ± 30.17	-0.1	0.88
Cholesterol: HDL Ratio	3.91 ± 1.15	NP	3.85 ± 1.24	-1.5	3.67 ± 1.16	NP	3.87 ± 1.44	1.2	0.15
TAG (mg/dL)	118.44 ± 40.42	NP	99.59 ± 44.77	-15.9	120.22 ± 67.45	NP	117.06 ± 63.39	-2.6	0.07
Glucose (mg/dL)	89.81 ± 8.04	NP	92.67 ± 7.74	3.2	90.56 ± 8.3	NP	94.56 ± 13.82	4.4	0.60
Adiponectin (pg/mL)	10.20 ± 0.81	10.16 ± 0.74	9.93 ± 0.76	-0.2	10.17 ± 8.80	10.05 ± 0.80	10.04 ± 0.83	-0.3	0.47, 0.15
Resistin (pg/mL)	82.74 ± 38.47	81.65 ± 36.72	69.63 ± 26.04	-15.8	86.77 ± 50.18	68.38 ± 32.11	81.57 ± 46.75	-5.9	0.08, 0.26
Leptin (pg/mL)	8.99 ± 0.88	8.93 ± 0.94	8.729 ± 1.25	-3.0	8.85 ± 1.09	8.36 ± 1.07	8.76 ± 1.25	-3.0	0.03*, 0.5
lL-6 (pg/mL)	0.45 ±0.83	0.37 ± 0.56	0.34 ± 0.94	-24.5	0.45 ± 1.22	0.38 ± 0.82	0.38 ± 1.44	-14.8	0.97, 0.89
TNF-α (pg/mL)	1.71 ± 1.16	1.45 ± 1.04	1.58 ± 1.08	-7.6	1.35 ± 1.82	1.53 ± 1.67	1.19 ± 1.25	-11.7	0.41, 0.49

Values are mean ± SD.
¹P values are for the differences between the two groups, METABO versus placebo at week 4 and week 8, respectively. No significant differences between the week 8 time points were noted using ANCOVA (where the week 0 time points were used as the covariate). * Significant difference at the week 4 mid time point for Leptin using ANCOVA. NP: not performed; HDL: high density lipoprotein; LDL: low density lipoprotein; TAG: triacylglycerols; IL-6: interleukin-6; TNF-α: tumor necrosis factor-α.

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